Rosie O'Donnell breaks down her exact Mounjaro dosage
Rosie O'Donnell breaks down her exact Mounjaro dosage on the "Bleep! With Ana Navarro" podcast, saying she spent a year each at 2.5 mg, 5 mg, and now 7.5 mg. The 64-year-old insists she has "never" had side effects after shedding about 60 pounds in three years on the GLP-1 drug.
Key Takeaways
- O'Donnell told podcast listeners Monday she took 2.5 mg of Mounjaro for a year, then 5 mg for a year, and is finishing a year at 7.5 mg.
- She plans to raise the dose "one more time" before holding steady.
- The former talk show host says she has "never" had side effects and prefers a "slow pace."
- She has lost about 60 pounds over three years and previously called the drug life-saving.
What Mounjaro dose did Rosie O'Donnell say she takes?
On Monday's episode of Bleep! With Ana Navarro, O'Donnell laid out a year-by-year plan. "I [did] the lowest dose for a year … 2.5 [milligrams]," she said. "Then I did a year at 5, and now I'm just finishing a year at 7.5."
The ex-View co-host said she only plans to increase the dosage "one more time" before leaving it alone. She explained that she wanted to go slow because rapid weight loss has overwhelmed her before, especially amid "everyone's reaction."
"I like doing it at a slow pace," she added. "I like how it feels that I'm not sick, that I've never had any kind of side effects."
Has Rosie O'Donnell had any Mounjaro side effects?
When Navarro asked whether she has ever "had to run to the bathroom" because of the GLP-1, O'Donnell answered flatly: "Never." She stressed that staying on 2.5 mg for a full year mattered. "The doctor kept saying, 'I want you to go up,' and I'm like, 'I'm fine as it is.'"
According to Page Six, O'Donnell first discussed being prescribed Mounjaro in January 2023 on TikTok, saying she had started about two months earlier in late 2022. At the time she had lost about 10 pounds and described a sharply reduced appetite.
She has since lost approximately 60 pounds. In a July interview with People, she credited the type 2 diabetes drug with "saving" her life and said she feels "much healthier and more powerful."
Why does her slow GLP-1 approach matter right now?
O'Donnell's detailed dosing timeline lands as other celebrities openly discuss GLP-1 drugs. Celebrity breaking news coverage has also followed stars like Kendra Wilkinson, who recently said an unnamed GLP-1 helped her drop more than two dress sizes and fit into old jeans again.
O'Donnell's account stands out because she pairs a multi-year, step-up schedule with a firm claim of zero side effects. She has also said she wishes she could do commercials for Mounjaro if it would help lower the price for people struggling with obesity.
Her podcast comments do not replace medical advice. They do, however, put a clear public number on how one high-profile patient says she used the drug: low and slow, over years—not months.